Author + information
- Leonardo Celeste Mangili,
- Marcio Miname,
- Otavio Mangili,
- Carlos Rochitte,
- Marcio Bittencourt and
- Raul Santos
Background: Achilles tendon xanthomas (ATX) have been considered as surrogates of long-term exposure to high blood cholesterol in familial hypercholesterolemia (FH) patients. We evaluated the ATX association with the presence and extent of subclinical coronary atherosclerosis (SCA) in heterozygous FH patients.
Methods: 102 FH patients diagnosed by US-MEDPED criteria (67% with proven FH causing genetic variants), median LDL-C 279 (interquartile range: 240; 313) mg/dL asymptomatic for cardiovascular disease that underwent computed tomography angiography and coronary artery calcium (CAC) quantification were studied. SCA was quantified by CAC, segment-stenosis (SSS) and segment-involvement (SIS) scores. Adjusted Poisson regression was used to assess the association of ATX with subclinical atherosclerosis burden as continuous variables.
Results: Patients with ATX (n=21, 21%) had higher LDL-C and lipoprotein(a) [Lp(a)] concentrations as well as greater CAC scores, SIS and SSS (Table). After adjusting for age, sex, smoking, hypertension, previous statin use, HDL-C and LDL-C concentrations, there was an independent positive association of ATX presence with CAC scores (beta =1.017, p<0.001), SSS (beta =0.809, p<0.001) and SIS (beta=0.640, p<0.001).
Conclusions: ATX are independently associated with the extension of SCA quantified by tomographic scores in FH patients.
Moderated Poster Contributions
Prevention Moderated Poster Theater, Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-9:55 a.m.
Session Title: Contemporary Issues in Familial Hypercholesterolemia
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1304M-03
- 2017 American College of Cardiology Foundation