Author + information
- Rikki Tanner,
- Lisandro Colantonio,
- Monika Safford,
- Keri Monda,
- Ben Taylor,
- Paul Muntner and
- Robert Rosenson
Background: Studies in select populations have shown that individuals who discontinue statins due to side effects can be successfully re-challenged.
Methods: We determined the prevalence and correlates of side effects experienced among REGARDS study participants who completed a statin use survey. We also determined whether willingness to be re-challenged with a statin differed by side effect.
Results: Among 1,023 REGARDS study participants who discontinued statins due to side effects, 82.0%, 10.1%, and 10.3% reported muscle pain, memory problems, and abnormal lab tests for liver or muscles as a reason for discontinuation, respectively. After multivariable adjustment, African Americans were less likely to report muscle pain, while women and obese participants were more likely to report muscle pain (Table). African American race and history of myocardial infarction were associated with a higher prevalence ratio for memory problems. Older adults and those with diabetes were less likely to report abnormal lab tests. Willingness to be re-challenged with a statin was reported by 18.5%, 16.5%, and 20.0% of those who discontinued therapy due to muscle pain, memory problems, and abnormal lab tests, respectively.
Conclusions: Muscle pain was the most common side effect experienced and few participants reporting any side effect were willing to be re-challenged on a statin.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Advances in Cholesterol Measurement and Management
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1106-044
- 2017 American College of Cardiology Foundation