Author + information
- Matthew Mefford,
- Robert Rosenson,
- Vera Bittner,
- Monika Safford,
- Rikki Tanner,
- April Carson,
- Ben Taylor,
- Keri Monda and
- Paul Muntner
Background: Previous studies have shown that medication intolerance may be affected by adverse events to medication and psychosocial factors. We investigated associations between quality of life, low self-rated health, stress and statin intolerance in a prospective cohort.
Methods: We examined the association between psychosocial factors and statin intolerance in the REGARDS study. Among participants who reported ever having taken a statin (n=5,967), statin intolerance was defined as having symptoms that the participant attributed to taking statins, that resolved after statin discontinuation and recurred following statin re-challenge. Psychosocial factors included self-rated general health, Short Form Survey (SF-12) physical component score (PCS) and mental component score (MCS), perceived stress (Cohen's perceived stress scale) and depressive symptoms, assessed using the 4-item Center for Epidemiologic Studies Depression (CESD) scale. Poisson regression was used to calculate prevalence ratios (PR) and 95% confidence intervals (CI) adjusting for age, sex, race, and other risk factors for statin intolerance.
Results: The mean age of the study population was 72.2 years, 29% of participants were black and 67% were women. Statin intolerance was present in 3.9% (n=231) of participants. After multivariable adjustment, the prevalence ratio for statin intolerance associated with poor versus excellent self-rated health was 1.50 (95% CI 0.64, 3.50). The prevalence ratio for statin intolerance comparing the lowest to highest quintiles of PCS and MCS were 1.51 (95% CI 0.99, 2.29) and 1.29 (95% CI 0.87, 1.91), respectively. The prevalence ratio for statin intolerance associated with high versus low perceived stress was 1.33 (95% CI 0.93, 1.90) and associated with depressive symptoms was 1.14 (95% CI 0.74, 1.75).
Conclusions: In REGARDS participants who have ever taken a statin, low physical function was associated with statin intolerance.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Advances in Cholesterol Measurement and Management
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1106-045
- 2017 American College of Cardiology Foundation