Author + information
- Georgios Benetos,
- Konstantinos Toutouzas,
- Iosif Koutagiar,
- Ioannis Skoumas,
- Spyros Galanakos,
- Angeliki Rigatou,
- Constantina Aggeli,
- Eleftherios Tsiamis,
- Elias Siores and
- Dimitris Tousoulis
Background: Premature atherosclerosis characterizes patients with familial hyperlipidemia (FH) syndromes. Statin therapy reduces systemic inflammation. Microwave radiometry (MWR) evaluates vascular inflammation via temperature measurements. We investigated in a randomized study the impact of statins on carotid wall inflammation in this specific patient group.
Methods: Familial hyperlipidemia patients (n=56), free of statin therapy for at least 6 months were randomized to either simvastatin 40 mg or simvastatin 40 mg plus ezetimibe 10mg. FH patients were randomized to either simvastatin 40 mg or simvastatin 40 mg plus ezetimibe 10mg. FH patients refusing statin therapy (n=10) constituted the control group for the assessment of statins effect. All the subjects underwent assessment of carotid temperatures (temperature difference-ΔT) using MWR. Carotid measurements and lipid profile assessment were performed at baseline and after 6 months.
Results: After 6 months, low-density lipoprotein (LDL) levels were reduced in FH patients who received statin therapy but not in control group (240.11± 103.64 vs 111.89±44.73, p<0.001 and 284.33±117.98 vs 246.33±44.02 mg/dl). Similarly, carotid temperatures were reduced in both simvastatin and simvastatin+ezetimibe groups (0.77±0.36 vs 0.51±0.21 °C, p=0.02 and 1.01±0.43 vs 0.58±0.27 °C, p=0.003, respectively), but they were not significantly influenced in control group (0.53±0.14 vs 0.83±0.43°C, p=0.15). The degree of temperature reduction did not differ significantly between simvastatin and simvastatin+ezetimibe group (p=0.26).
Conclusions: Simvastatin therapy among the beneficial effect on LDL levels, reduced carotid wall inflammation in FH patients. The additive role of ezetibime to simvastatin on carotid disease remains to be further investigated in this specific population.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Advances in Cholesterol Measurement and Management
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1106-052
- 2017 American College of Cardiology Foundation