Author + information
- Anum Saeed,
- Christie Ballantyne,
- Wensheng Sun,
- Gerardo Heiss,
- Thomas Mosley,
- Cameron Guild,
- Eric Boerwinkle,
- Elena Feofanova,
- Yu Bing,
- Salim Virani,
- Josef Coresh,
- Vijay Nambi and
- Ron Hoogeveen
Background: Lipolysis of triglyceride-rich lipoproteins (TGRLs) produces remnant lipoproteins enriched with cholesterol, known as remnant-like particle cholesterol (RLPC). Elevated TGRLs also dysregulate LDL metabolism, which may increase TG content in LDL (LDL-TG). Evidence suggests RLPC and LDL-TG are atherogenic. We examined the association of RLPC and LDL-TG with incidence of cardiovascular (CV) events.
Methods: Plasma RLPC and LDL-TG levels were measured by automated homogeneous assays (Denka Seiken, Tokyo) in 9,334 men and women without prevalent coronary heart disease (CHD) or stroke at baseline (visit 4, 1996-1999) in the biracial ARIC study. Cox proportional-hazards models were used to examine the relation between RLPC and LDL-TG, CV risk factors, and risk for CV events including MI and ischemic stroke over a mean of 16 y. Data were assessed in quartiles and as continuous variables.
Results: RLPC and LDL-TG levels were higher in individuals with diabetes than those without diabetes and correlated with elevated TG (p<0.005). RLPC and LDL-TG were associated with increased CV risk in minimally adjusted models. After adjusting for CV risk factors, LDL-TG remained significantly associated with risk of incident CHD and ischemic stroke but RLPC did not (Table).
Conclusions: In a large biracial cohort, LDL-TG was associated with incidence of CHD and ischemic stroke after adjusting for CV risk factors but RLPC was not. Studies are needed to examine LDL-TG as a risk marker and risk factor for CHD and stroke.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Advances in Cholesterol Measurement and Management
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1106-068
- 2017 American College of Cardiology Foundation