Author + information
- Stephen M. Amrock,
- Bart Duell,
- Thomas Knickelbine,
- Seth Martin,
- Peter Shrader,
- Emily O'Brien,
- Karol Watson,
- Joanna Mitri,
- Iris Kindt,
- Joshua Knowles,
- Zahid Ahmad,
- on behalf of the CASCADE-FH Investigators
Background: Familial hypercholesterolemia (FH) patients require aggressive lipid lowering therapies to reduce cardiovascular disease risk. In the US, treatment patterns remain poorly described, and it remains unclear whether sex or ethnic/racial disparities exist. In 2013, the FH Foundation launched the CAscade SCreening for Awareness and DEtection (CASCADE-FH) registry to address such knowledge gaps.
Methods: Data from 3167 adults (61% women) were analyzed. We used logistic regression to assess the association of sex and ethnicity with achievement of LDL-C levels and statin use.
Results: Men and women had similar pretreatment LDL-C (median [IQR], women 236 [209-286] vs men 231 [206-289]; p = 0.17). Yet women were diagnosed at older ages (59 [48-67] vs. 54 [42-63] yrs; p < 0.0001), were less likely to achieve treated LDL-C <100 mg/dL (OR 0.64 [95% CI 0.56-0.73]) or treated LDL-C <70 mg/dL (OR 0.70 [0.52-0.95]), less likely to take any statin (OR 0.56 [0.39-0.80]), and less likely to take a high-intensity statin (OR 0.52 [0.41-0.66]). Several differences were noted after stratifying by ethnicity/race (Table 1). For example, blacks were diagnosed later than other groups, and blacks and Asians had higher treated LDL-C despite having similar pretreatment LDL-C.
Conclusions: Our findings imply health disparities in the care of US FH patients. Women and blacks were diagnosed at older ages and had higher treated LDL-C. Efforts to address these disparities among FH patients are needed to improve health equity.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Current Issues in Cardiovascular Epidemiology, Disparities, and Safety
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1148-056
- 2017 American College of Cardiology Foundation