Author + information
- Anselm K. Gitta,b,
- Dominik Lautscha,b,
- Martin Horacka,b,
- Philippe Brudia,b,
- Larry Liua,b and
- Jean Ferrièresa,b
Background: Recent guidelines of EAS/ESC as well as AHA/ACC recommend LDL-C <70 mg/dl in very high risk patients. Despite chronic statin treatment, only a minority of patients achieve this target.
Methods: Between 2008 and 2012, consecutive statin-treated outpatients were enrolled in 26 countries including Europe, Canada, South-Africa, Middle East and China, (DYSIS = Dyslipidemia International Study) to assess LDL-C goal attainment for secondary prevention. Data were collected under real life conditions in the outpatient setting. We examined the impact of female gender on LDL-target-achievement.
Results: A total of 46,310 patients of DYSIS were at very high risk, of whom 18,653 (40.3%) were females. Female patients were older, more often had risk factors such as hypertension and diabetes, but less often suffered from already manifest ischemic heart disease as compared to the male population. Females more often were treated with less potent statins as well as with lower doses of statins independent on the statin used. Even after correcting for differences in baseline characteristics female gender was an independent predictor of not achieving LDL-C-targets in clinical practice (OR 0.68; 95%CI 0.47-0.97).
Conclusions: Female patients were treated with less potent statins as well as with lower doses of statins in clinical practice. They had a 32% lower chance to reach the LDL-C-targets currently recommended by guidelines.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Current Issues in Cardiovascular Epidemiology, Disparities, and Safety
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1148-057
- 2017 American College of Cardiology Foundation