Author + information
- Satish Ramkumara,b,
- Hong Yanga,b,
- Ying Wanga,b,
- Mark Nolana,b,
- Kazuaki Negishia,b and
- Thomas Marwicka,b
Background: Left atrial (LA) dysfunction is associated with adverse prognosis in HFpEF. We sought whether LA dysfunction was associated with incident HF, independent of hypertension (HTN).
Methods: In a community study (n=576,age 71±5y), participants≥65 years with >1 risk factors (HTN,diabetes,obesity) underwent echo and strain analysis (P-P gating for LA strain). Pts were assigned to four groups (no HTN, controlled HTN(SBP<150mmHg), active HTN(SBP≥150mmHg) and HTN+LVH). The relationship between afterload and atrial strain was investigated using linear regression. Pts were followed for incident HF (Framingham criteria).
Results: LVH had reduced LV strain (GLS) and increased LA volume (p<0.05). Pts with active HTN or LVH had reduced atrial reservoir, conduit and pump strain compared to pts without (or well controlled) HTN (p<0.05). E/e’ and GLS (but not SBP and LV mass) were independently associated with atrial reservoir strain (Table). LA volume was independently associated with atrial pump strain (p<0.001) (Table). Of the 478 pts with 12 month follow up, 54(11%) developed new HF. Reduced GLS (HR 1.2,95% C.I 1.1-1.3,p=0.001) but not atrial strain (p>0.05) was associated with incident HF
Conclusions: LA reservoir function appears to be independent of BP, but is related to LV strain and diastolic pressure. Despite its prognostic role in established HF, LA function is not predictive of incident HF.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Toward Precision Medicine in the Treatment of Elevated Blood Pressure
Abstract Category: 33. Prevention: Hypertension
Presentation Number: 1186-036
- 2017 American College of Cardiology Foundation