Author + information
- Timothy S. Phan,
- Amer Ahmed Syed,
- Harry Garrett Oldland,
- Nicolas Sanchez,
- Zeba Hashmath,
- Scott R. Akers and
- Julio A. Chirinos
Background: Carotid-femoral pulse wave velocity (cfPWV) is considered one of the standard methods to estimate aortic stiffness. Its requirement of a technically-skilled operator has motivated development of automated systems to measure PWV. Heart-femoral PWV (hfPWV) can be automatically measured in an operator-independent manner with cuff-based systems.
Methods: We studied 73 older adults (mean age=66 yrs) from a clinical population. We measured cfPWV using applanation tonometry (SphygmoCor) and hfPWV with the VaSera VS-1500AU (Fukuda Denshi) incorporating a novel thigh-cuff prototype.
Results: cfPWV and hfPWV demonstrated significant changes with age (ANOVA P<0.001; Figure). hfPWV demonstrated tighter confidence intervals, particularly from 5th to 7th decade of life. Effect-size for hfPWV (ν2=0.40) was higher than cfPWV (ν2=0.24). After adjustment for sex, BMI, mean arterial pressure, and heart rate, age remained more explanatory of variance in hfPWV (R2=0.44) than cfPWV (R2=0.34).
Conclusions: hfPWV is a stronger marker of arterial aging than cfPWV. The operator-dependency of tonometry may introduce more noise than the fully automated cuff-based system. Automated cuff-based hfPWV may lower the barrier to clinical adoption of phenotyping arterial stiffness as a sensitive biomarker of arterial aging.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Toward Precision Medicine in the Treatment of Elevated Blood Pressure
Abstract Category: 33. Prevention: Hypertension
Presentation Number: 1186-039
- 2017 American College of Cardiology Foundation