Author + information
- Andres Palomo,
- Roberta M. Ray,
- Lisa Johnson,
- Electra Paskett,
- Bette Caan,
- Lee Jones and
- Tochi Okwuosa
Background: Cardiovascular disease is the leading cause of death among breast cancer survivors. Whether exercise prior to and around the time of breast cancer diagnosis reduces the risk of cardiovascular events (CVE) in survivors subsequent to treatment is unknown.
Methods: Among 4015 participants with non-metastatic breast cancer in the WHI study, we compared questionnaire-completed physical activity (PA) levels (in metabolic equivalent task [MET]-hrs/wk) to age and multivariable-adjusted (MA) risk of CVE (defined as heart failure, MI, angina, coronary revascularization, PAD, carotid artery disease, TIA, stroke, and cardiovascular death) in the years post treatment.
Results: The median follow-up was 12.7 years. We observed a decreasing trend in MA hazard ratios (HR) for CVE (342) and coronary heart disease (CHD) deaths (96) across increasing levels of PA (Table); HR (95% confidence interval [CI]): 0.59 (95% CI 0.43 to 0.80) for CVE and 0.41 (0.21 to 0.78) for CHD death in the highest quartile of ≥ 18.00 MET vs. referent quartile of < 2.5 MET hrs/wk (p for trend across quartiles: 0.001 & 0.006, respectively). Comparing ≥ 9MET-hrs/wk (n=1976) vs. < 9 MET-hrs/wk (n=2039), HR was 0.77 [95% CI 0.62 to 0.95] for CVE (age-adjusted) and 0.56 (95% CI 0.35 to 0.89) for CHD death (age and MA); p: 0.02 & 0.01, respectively.
Conclusions: Higher levels of exercise prior to and around the time of breast cancer diagnosis are associated with decreased risk of CVE and CHD deaths in the years after breast cancer diagnosis and treatment.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-045
- 2017 American College of Cardiology Foundation