Author + information
- Brad Peden,
- Ambarish Pandey,
- Colby Ayers and
- Jarett Berry
Background: Independent contributions of objectively measured sedentary time (ST), physical activity (PA), and cardiorespiratory fitness (CRF) towards cardiometabolic risk factors and left ventricular (LV) structure and function are not well established.
Methods: We included 1,398 participants from the Dallas Heart Study (age 49 years; 40% women) free of CVD. PA and ST were measured by accelerometer (Actical) and CRF was estimated from a submaximal treadmill test. ECG-gated tissue-tagged cardiac MRI imaging was performed using 3-T MRI. A series of linear regression models were constructed to evaluate the associations of ST, PA, and CRF with cardiometabolic (insulin resistance, lipid levels) and LV parameters after adjustment for established CV risk factors.
Results: Higher CRF was associated with larger left atrial volume, LV mass, stroke volume, and more negative (more normal) LV strain. Higher CRF was also associated with lower triglycerides and less insulin resistance. In contrast, higher PA was not associated with any cardiac imaging phenotype but was associated with lower triglycerides and higher HDL-c. ST was not associated with either of the two intermediate phenotypes (table).
Conclusions: After accounting for CRF and PA, we observed no consistent associations between ST and cardiometabolic or LV parameters. In contrast, CRF was associated with both of these intermediate phenotypes. These findings suggest that there may be no independent effects of ST on HF risk after accounting for CRF.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-046
- 2017 American College of Cardiology Foundation