Author + information
- Serge C. Harb,
- Yuping Wu,
- Leslie Cho,
- Carol Rouphael,
- Paul Cremer,
- Venu Menon and
- Wael Jaber
Background: Physical inactivity is a major health problem. We sought to determine the relationship between exercise time and survival in patients referred for exercise treadmill testing (ETT).
Methods: All pts who underwent ETT (exercise ECG, echo and nuclear) at our institution, between Jan. 1991 and Feb. 2015, were included. Exercise time was recorded in seconds (sec). Survival at 10 years was determined using the Social Security Death Index (SSDI) and institutional death status. Uni and Multi-variate Cox regression models were used to determine the impact of exercise time on survival and a restricted cubic spline plot was computed to determine its association with the risk of death, stratified by gender.
Results: A total of 126.356 pts were included. Mean age was 53.5 years and 59% were male. At 10 year follow-up, 9929 (8%) died. Median exercise time was 570 sec (473-660) in males and 480 sec (360 -557) in females. Using the median exercise time of 540 sec as the cutoff, lower exercise time was associated with a higher risk of death [HR: 1.22 (1.19-1.25), p<0.001]. After adjusting for cardiac risk factors, an exercise time <540 sec. conferred about a two-fold increased risk of death [HR: 2.06 (1.95-2.17), p<0.001] and was the major determinant of death, after age. Figure 1 shows the restricted cubic spline plot for the risk of death by exercise time and gender.
Conclusions: In patients referred for stress testing, decreasing exercise time was associated with increased risk of death in both genders with no plateau effect.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-047
- 2017 American College of Cardiology Foundation