Author + information
- Shreya Rao,
- Ambarish Pandey,
- Sushil Garg,
- Bryan Park and
- Ian Neeland
Background: Increased BMI and visceral adipose tissue (VAT) are associated with elevated risk of adverse cardiovascular outcomes. While several exercise and pharmacological interventions have been shown to reduce BMI, their impact on VAT is not well established.
Methods: We included randomized controlled trials (RCTs) that evaluated the efficacy of exercise or pharmacological interventions in VAT reduction. Outcome assessed was change in visceral fat area (cm2) using CT or MRI imaging. Separate pooled analysis was using random-effect models with pooled estimates of change in VAT from baseline to following reported as standardized mean difference (SMD). Magnitude of effect was compared based on SMD estimates.
Results: The primary analysis included 4,380 participants from 25 RCTs. In pooled analysis, both exercise training and pharmacological interventions were associated with significant reductions in visceral adiposity (see figure). Exercise training was associated with a moderate reduction in VAT measures [SMD (95% CI): -0.71 (-0.93 to -0.49)]. In contrast, more substantial decrease in VAT was observed with pharmacological therapies [SMD (95% CI): -0.91 (-1.42 to -0.40)].
Conclusions: Exercise and pharmacologic interventions are associated with significant reduction in VAT, with more substantial benefits from pharmacological therapies. Future studies are needed to determine if the favorable effects of these interventions may also lower the risk for adverse cardiovascular outcomes.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-049
- 2017 American College of Cardiology Foundation