Author + information
- Pyung Chun Oh,
- Woong Chol Kang,
- Minsu Kim,
- Jeonggeun Moon,
- Kyounghoon Lee,
- Eak Kyun Shin,
- Jon Suh,
- Hyun Woo Park,
- Ho-Jun Jang,
- Tae-Hoon Kim,
- Sang-Don Park and
- Sung Woo Kwon
Background: Serum alkaline phosphatase (ALP) level has been shown to be a prognostic factor in several subgroups of patients via its promotion of vascular calcification. We aimed to investigate the prognostic impact of ALP level measured at the time of presentation on clinical outcomes in patient with ST-segment elevation myocardial infarction (STEMI) requiring primary percutaneous coronary intervention (PCI).
Methods: A total of 1178 patients with STEMI undergoing primary PCI between 2007 and 2014 were retrospectively enrolled from the INTERSTELLAR registry and were classified into tertiles by ALP levels (<64, 65-82, >83 IU/L). Primary outcome was major adverse cardiac and cerebrovascular event (MACCE), defined as the composite of all-cause death, non-fatal myocardial infarction, non-fatal stroke and ischemia-driven revascularization.
Results: The median duration of follow-up was 25 months (interquartile range, 10-39 months). The incidence of MACCE significantly increased as ALP level gets higher among the tertiles (8.7% vs. 11.7% vs 15.7%, respectively, P for trend=0.003). After adjustment of potential confounders, adjusted hazard ratios of MACCE in the middle and highest tertiles were 1.69 (95% CI 1.01-2.81) and 2.46 (95% CI 1.48-4.09), respectively, compared with the lowest ALP tertile.
Conclusions: Increased levels of ALP measured at the time of presentation, almost within normal range, were independently associated with higher risk of MACCE after primary PCI in patients with STEMI.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Cardiac Arrest, Diabetes, and Other High Risk Features of Patients With Acute Coronary Syndrome
Abstract Category: 2. Acute and Stable Ischemic Heart Disease: Clinical
Presentation Number: 1204-332
- 2017 American College of Cardiology Foundation