Author + information
- Rupa L. Iyengar,
- Cynara Maceda and
- Mary Ann McLaughlin
Background: Exposure to particulate matter (PM) is a risk factor for cardiovascular disease (CVD). Different mechanisms, including inflammatory processes, are responsible for acute and chronic toxic effects. First responders during the World Trade Center (WTC) tragedy were exposed to PM leading to potential increased CVD risk. We aim to see if there is an interaction over time related to increased CVD risk from exposure to PM.
Methods: We evaluated 356 participants three discrete WTC screening events. All participants were law enforcement officers who participated in rescue and recovery at Ground Zero. CVD 10 year risk was calculated using Framingham Risk Score. WTC exposure scores were defined as three exposure groups (XP3) and four exposure groups (XP4). ANOVA and generalized linear model in repeated measures analysis were performed in SAS 9.4.
Results: Analysis between CVD risk and exposure in XP3 (Table 1A) and XP4 (Table 1B) showed no significance at a single time point. Analysis of change over time reveals a significant interaction between CVD Risk and XP3 as well as XP4 with p-value of 0.008 and 0.03 respectively. Within XP3 for intermediate exposure was significantly associated with increased CVD risk over time (p=0.015) and trended to significance for XP4 (p=0.054).
Conclusions: A significant effect is seen between PM and increased CVD risk over time. These findings suggest that the level of chronic lower levels of exposure may have greater impact on CVD risk compared with acute intense PM exposure.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-052
- 2017 American College of Cardiology Foundation