Author + information
- Joshua P. Rivers,
- Amit Dey,
- Abhishek Chaturvedi,
- Jonathan Chung,
- Mohammad Tarek Kabbany,
- Mark Ahlman,
- Justin Rodante,
- Aditya Joshi,
- Charlotte Harrington,
- Martin Playford,
- Jianhua Yao,
- Tiffany Powell-Wiley and
- Nehal Mehta
Background: Psoriasis, a chronic inflammatory disease, is associated with vascular inflammation (VI) by FDG PET/CT and increased cardiometabolic dysfunction including adipose tissue dysregulation. Recently, visceral adiposity (VAT) was shown to associate with cardiovascular events in non-psoriasis patients, however, association of VI by FDG PET/CT with VAT compared to subcutaneous adiposity (SAT) is not known. Therefore, we sought to compare the association of VAT and SAT with VI by FDG PET/CT beyond cardiovascular risk factors.
Methods: Consecutively recruited psoriasis patients (N=77) underwent FDG PET/CT scans to measure VI and abdominal adiposity represented as target-to-background ratio (TBR) and cm3 respectively. VAT and SAT volume was quantified from vertebral level T10 to pelvis by CT. The relationship of VAT and SAT with VI was analyzed using multivariable regression models (STATA 12).
Results: The cohort had a low Framingham Risk Score [Median (IQR); 4(2-7)] and mild to moderate psoriasis [Median (IQR); 5.2 (3.0-8.5)]. VAT remained significantly associated with TBR (beta = 0.45, p = 0.002) while SAT did not retain significance (beta = -0.04, p = 0.84) following adjustment for BMI (Table).
Conclusions: VAT significantly associated with TBR, while SAT attenuated significance when adjusting for BMI. This supports the concept that VAT may modulate vascular inflammation directly, whereas SAT operates via BMI. Larger studies are needed to confirm these findings.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-064
- 2017 American College of Cardiology Foundation