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Background: Body fat distribution has been implicated in the pathogenesis of cardiovascular diseases (CVD) and diabetes mellitus (DMII). The influence of a family history of cardiometabolic disease, as a surrogate for genetic risk, on fat distribution is unknown.
Methods: Participants without CVD or DMII in the Dallas Heart Study underwent assessment of family history (CVD, hypertension, DMII, stroke, or heart failure) by interview and body fat distribution by MRI and DXA. Multivariable-adjusted associations between family history and fat profile were assessed by linear regression.
Results: The study cohort (n=1,881) had a mean age 44 years and was 54% male, 55% African American, with mean BMI 29 kg/m2. 81% had one or more family history factors and the mean number of factors was 1.8. Those with a family history of cardiometabolic disease had higher blood pressure, total cholesterol and LDL cholesterol (p<0.05 for all). After multivariable adjustment, a family history of DMII was significantly associated with less lower body fat but the relationships of family history with other fat depots were not significant (Table).
Conclusions: A family history of cardiometabolic disease is not independently associated with fat distribution in the general population. Family history of DMII may be associated with less lower body fat, a protective fat depot. Environmental factors may play a more important role in fat distribution, suggesting a fundamental role for lifestyle modification in the treatment of obesity.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-065
- 2017 American College of Cardiology Foundation