Author + information
- Yan Yi Cheung,
- Bee-Choo Tai,
- Germaine Loo,
- See-Meng Khoo,
- Yin-Phoon Cheong,
- Ferran Barbe and
- Chi-Hang Lee
Background: There is increasing awareness that health screening may prevent some catastrophic coronary events. Yet, obstructive sleep apnea (OSA) is seldom screened for and its relationship with coronary risk markers is not well established.
Methods: Consecutive adults (n=696) enrolled in a cardiovascular health screening program were approached for an OSA screening using a FDA-approved home-based diagnostic sleep device. High-sensitivity C-reactive protein (hs-CRP) was the primary coronary risk marker, and other laboratory- and exercise treadmill-based markers were also reported.
Results: Two-thirds (65.7%) of the participants agreed to undergo OSA screening and most (78.3%) successfully completed the sleep study. The prevalence of OSA (apnea-hypopnea index ≥15/hour) was 38.0%. After full adjustment (Table), OSA remained an independent predictor of serum levels of hs-CRP (relative mean difference 1.29; 95% CI 1.03 to 1.62; p=0.025), triglyceride (relative mean difference 1.15; 95% CI 1.03 to 1.28; p=0.014), and exercise time (mean difference 26.4 s; 95% CI 1.2 to 51.6; p=0.04). The InterHeart Risk Score analysis suggested more participants with (30.7%) than without (14.3%, p<0.001) OSA will develop future cardiovascular events.
Conclusions: Based on the acceptance for OSA screening, high prevalence of OSA and independent associations between OSA and coronary risk markers, incorporation of sleep studies into cardiovascular health screening programs appears feasible.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-068
- 2017 American College of Cardiology Foundation