Author + information
- Chayakrit Krittanawonga,b,
- Anusith Tunhasiriweta,b,
- Zhen Wanga,b,
- Hongju Zhanga,b,
- Larry J. Prokopa,b,
- Sakkarin Chirapongsathorna,b,
- Mehmet Aydara,b,
- Tao Suna,b and
- Takeshi Kitaia,b
Background: Short sleep duration has been identified as a risk factor for cardiovascular diseases (CVD) and mortality. It has been hypothesized that short sleep duration may be linked to changes in ghrelin/leptin production leading to alteration of stress hormone production. Here, we conducted systematic review and meta-analysis to investigate the evidence in support of the presence of a relationship between either short or long duration of sleep and CVD mortality.
Methods: We conducted a comprehensive search of Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, and Scopus from database inception through July 2016. Observational studies were included if the studies reported hazard ratios (HRs) or odd ratios (ORs) of the associations between sleep duration (short and long) and CVD mortality. Data were extracted by one reviewer and then reviewed by two independent reviewers. Conflicts were resolved through consensus. Using the DerSimonian and Laird random effects models, we calculated pooled HRs and pooled ORs with 95% confidence intervals (95% CIs). Subgroup analyses were performed to explore potential sources of heterogeneity. The quality of the included studies and publication bias were assessed.
Results: In total, our meta-analysis included 18 studies (31 cohorts) with a total of 835,731 individuals with 42,870 CVD mortality cases. In the pooled analysis, short duration of sleep was associated with greater risk of CVD mortality (RR: 1.19; 95% CI 1.13 to 1.26, P < 0.001, I2 = 30.7, Pheterogenuity = 0.034). similarly, long duration of sleep was associated with greater risk of CVD mortality (RR: 1.37; 95% CI 1.23 to 1.52, P < 0.001, I2 = 79.75, Pheterogenuity < 0.001).
Conclusions: Both short (< 7 hrs) and long sleep duration (> 9 hrs) can causes the risk of overall CVD mortality, particularly in Asian populations and elderly. Future epidemiological studies would ideally include objective sleep measurement rather than self-reported and all potential confounders such genetic variants.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-069
- 2017 American College of Cardiology Foundation