Author + information
- Thorarinn Arni Bjarnasona,b,
- Steinar Hafthorssona,b,
- Linda Kristinsdottira,b,
- Erna Óskarsdóttira,b,
- Thor Aspelunda,b,
- Sigurdur Sigurdssona,b,
- Vilmundur Gudnasona,b and
- Karl Andersena,b
Background: Type 2 diabetes (T2DM) and prediabetes are established risk factors for atherosclerosis. The aim of this study was to evaluate the atherosclerotic plaque burden in the carotid arteries of acute coronary syndrome (ACS) patients according to their glycemic status.
Methods: Patients admitted to the coronary care unit with ACS and no previous history of T2DM were consecutively included in the study. Glucose metabolism was evaluated with fasting glucose in plasma, HbA1c and a standard two-hour OGTT before hospital discharge and repeated three months later. Atherosclerotic plaques in the common carotid arteries (CCA) were evaluated with a standardized ultrasound examination where total plaque area (TPA) in the CCA was measured and patients classified as having no plaque or a significant plaque formation.
Results: A total of 245 ACS patients (male 78%, mean age 64 years) were included in the study. The proportion diagnosed with normal glucose metabolism (NGM), prediabetes and T2DM was 28.6%, 64.1% and 7.3%, respectively. Significant atherosclerotic plaques were found in 48.5%, 66.9% and 72.2% of patients with NGM, prediabetes and T2DM, respectively. An incremental increase was in TPA from NGM to T2DM with 25.5% and 35.9% increase among patients diagnosed with prediabetes and T2DM, respectively, compared to patients with NGM (p = 0.04). The adjusted odds ratio (OR) for patients with newly diagnosed dysglycemia of having significant atherosclerotic plaque in the CCA was 2.17 (95% CI 1.15-4.15) compared to patients with NGM.
Conclusions: A high prevalence of carotid atherosclerotic plaque is found in patients with ACS with incremental increase from NGM to T2DM. Newly detected dysglycemia in patients with ACS is an independent predictor of atherosclerotic plaque in the CCA.
Poster Hall, Hall C
Saturday, March 18, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Updates on Risk Factors for Cardiovascular Disease
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1187-070
- 2017 American College of Cardiology Foundation