Author + information
- Nidhi Madan,
- Alexandra Lee,
- Kunihiro Matsushita,
- Ron Hoogeveen,
- Christie Ballantyne,
- Elizabeth Selvin and
- John McEvoy
Background: We set out to test the prevalence of isolated systolic hypertension (ISH) and wide pulse pressure (PP), both proxies for vascular stiffness, among a modern cohort of older adults and to determine whether any association with high sensitivity cardiac troponin-T (hs-cTnT) and NT-pro BNP and these blood pressure (BP) parameters was evident.
Methods: We conducted a cross-sectional analysis of 5251 participants of the biracial Atherosclerosis Risk in Communities (ARIC) Study, 65 years or older without heart failure (visit 5, 2011-2013). Logistic regression was used to evaluate the association of ISH (Systolic BP≥140 mmHg and Diastolic BP<90 mmHg and quartiles of PP with detectable hs-cTnT (≥5ng/L), elevated hs-cTnT by sex-specific 99th percentile cut-offs (>17 ng/L for women and >31 ng/L for men) and elevated NT-pro BNP (≥100 pg/mL).
Results: Mean age was 75 years, 58% were female, and 78% were white. ISH was highly prevalent in this cohort (25%) and strongly associated with elevated hs-cTnT and NT-pro BNP compared to persons without ISH even after rigorous adjustment (Table). PP was also significantly associated with elevated both hs-cTnT and NT-proBNP (p-for-trend <0.0001).
Conclusions: In a modern sample of older adults, ISH and widening PP are highly prevalent and, based on higher levels of hs-cTnT and NT-pro-BNP, elderly individuals with these BP aberrations are at increased risk for cardiovascular disease and heart failure.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Markers of Prognosis Associated With Elevated Blood Pressure
Abstract Category: 33. Prevention: Hypertension
Presentation Number: 1234-034
- 2017 American College of Cardiology Foundation