Author + information
- Timothy S. Phan,
- Harry Garett Oldland,
- Khuzaima Javaid,
- Uzma Kewan,
- Izzah Vasim,
- Swapna Varakantam,
- Scott R. Akers and
- Julio A. Chirinos
Background: Aortic stiffness (AS) is an important mediator of CVD risk with aging. Operator-independent methods to assess AS are needed. Cardio-ankle vascular index (CAVI) is a noninvasive estimate of AS that can be automatically measured with cuff-based systems. Its specificity to AS as a marker of arterial aging is potentially complicated by inclusion of a muscular path (femoral-tibial). We hypothesize that a new cardio-femoral vascular index (CAFI) is a stronger and more relevant marker of aortic aging.
Methods: We studied 118 adults (mean age=65 yrs) from a clinical population. CAVI was measured with the VaSera VS-1500AU (Fukuda Denshi). We incorporated a novel thigh-cuff prototype to measure CAFI. Heart-ankle pulse wave velocity (haPWV), heart-femoral PWV (hfPWV), and femoral-ankle PWV (faPWV) were automatically computed.
Results: CAFI and CAVI increased significantly with age (ANOVA P<0.001; Figure). Similarly, haPWV and hfPWV increased significantly with age (ANOVA P<0.001) but faPWV did not (ANOVA P=0.66; Figure). The effect-size for CAFI (ν2=0.382) was greater, indicating that age explained 38.2% of the variance in CAFI, compared with CAVI (ν2=0.292). After adjustment for sex, BMI, heart rate and mean arterial pressure, age remained more strongly explanatory of CAFI (R2=0.38) than CAVI (R2=0.28).
Conclusions: The muscular path incorporated in CAVI demonstrated insignificant changes with age and confounds CAVI as a marker of aortic aging; CAFI is a stronger marker and is more relevant to AS.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Markers of Prognosis Associated With Elevated Blood Pressure
Abstract Category: 33. Prevention: Hypertension
Presentation Number: 1234-037
- 2017 American College of Cardiology Foundation