Author + information
Background: There is increased risk of major adverse cardiac events (MACE) in patients with systemic lupus erythematosus (SLE), although the optimal risk stratification strategy is unknown. Red cell distribution width (RDW) has been shown to independently predict MACE, including myocardial infarction (MI), heart failure (HF), and stroke (CVA) in various populations. We sought to investigate whether RDW is useful in predicting MACE in the SLE population.
Methods: In June 2016, we performed a retrospective cohort analysis using a large, multi-institutional database (Explorys Inc, Cleveland, OH). 10-year (June 2007 to May 2016) cumulative incidence of MACE were compared between those with and without SLE, graded by RDW quintiles (≤13.2, 13.3-13.9, 14.0-14.6, 14.7-15.7, ≥15.8).
Results: We identified 69,620 patients with SLE and 14,825,240 controls. There was a graded increase by RDW quintiles in 10-year cumulative incidence of MACE in the SLE group: MI (2.48% – 3.67% – 4.82% – 7.42% – 12.61%), HF (2.74% – 4.11% – 6.36% – 10.65% – 24.65%), and CVA (0.09% – 0.17% – 0.72% – 0.83% – 1.30%). A similar trend was observed in the control group, although absolute incidence were significantly lower (Figure). This graded relationship persisted when adjusted for gender and anemia.
Conclusions: MACE occur significantly more frequently in patients with SLE compared with controls. RDW is correlated with higher incidence of MACE in graded fashion, and may be useful for further risk stratification in this population.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Innovations in Cardiovascular Risk Assessment and Reduction
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1235-039
- 2017 American College of Cardiology Foundation