Author + information
Background: We conducted this nationwide cohort study to identify the predictive role of CHA2DS2-VASc score for ischemic stroke risk stratification in chronic obstructive pulmonary disease (COPD) patients whether they had comorbid atrial fibrillation (AF) or not.
Methods: The study COPD patients were divided into 2 cohorts stratified by concomitant AF or not. We calculated the CHA2DS2-VASc score -specific incidence density rates of ischemic stroke with person-years in each cohort. Cox models were conducted to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of ischemic stroke risk in COPD patients with or without concomitant AF. The predictive performance of CHA2DS2-VASc score with regard to ischemic stroke events was assessed using area under the curve (C-statistic) in the presentation of receiver operating characteristic curve.
Results: COPD patients with a higher CHA2DS2-VASc score were more likely to develop ischemic stroke whether or not with comorbid AF (P<0.001). Moreover, among COPD patients without AF, the C-statistic of CHA2DS2-VASc score predictive of ischemic stroke was 0.71(95% CI = 0.70-0.72) whereas the C-statistic was 0.58 (95% CI = 0.55-0.62) in COPD patients with AF.
Conclusions: Our study was the first to show that CHA2DS2-VASc score is useful in stroke risk stratification in COPD patients with or without concomitant AF, and the predictive performance is better for COPD patients who had no comorbid AF.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Innovations in Cardiovascular Risk Assessment and Reduction
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1235-049
- 2017 American College of Cardiology Foundation