Author + information
- Aristotelis Papayannis,
- Daniel Duprez,
- Chetan Shenoy,
- Joachim Ix,
- Myron Gross,
- Jorge Kizer,
- Jose Luchsinger and
- David Jacobs
Background: Procollagen Type III NTerminal Propeptide (PIIINP) and Collagen Type I CarboxyTerminal Telopeptide (ICTP) reflect collagen turnover. We hypothesized that PIIINP and ICTP are associated with coronary artery calcium (CAC) and its progression in subjects free of overt cardiovascular disease (CVD).
Methods: In MESA, 1,342 subjects (mean age 58 ± 12 years, 37% male), free of overt CVD, had 0 CAC at baseline and measurement at 1.5, 3, 5, and/or 10 years. Plasma PIIINP and ICTP levels were performed at baseline. The odds ratio (OR) for CAC per standard deviation (SD) of log of PIIINP and ICTP and probability of incident CAC per quartile were calculated (logistic regression), adjusting for age, race, sex, eGFR, number of CAC measurements, height, BMI, heart rate, systolic and diastolic blood pressure (BP), smoking, cholesterol (chol), HDL-chol, triglycerides, BP and chol lowering medications, diabetes, CRP.
Results: Mean±SD for ICTP was 3.15±1.37 µg/L and PIIINP was for 5.41±1.91 µg/L. 279 Subjects had incident CAC, graded by ICTP. Table shows the gradient and the probability of incident CAC increasing over ICTP quartile from 0.15 to 0.23 (pairwise differences all significant except for quartiles 1 vs 2 and 3 vs 4). There was no association between ICTP and CAC progression and between PIIINP and CAC.
Conclusions: ICTP but not PIIINP, predicts CAC incidence independently from other CV risk factors in asymptomatic subjects with 0 CAC at baseline.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Innovations in Cardiovascular Risk Assessment and Reduction
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1235-050
- 2017 American College of Cardiology Foundation