Author + information
- Hongjian Wanga,b,
- Noel T. Muellera,b,
- Jianping Lia,b,
- Ninglin Suna,b,
- Yong Huoa,b,
- Fazheng Rena,b and
- Xiaobin Wanga,b
Background: The role of maternal folate concentrations, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorder, diabetes and prepregnancy obesity), in child systolic blood pressure (SBP) has not been examined in a prospective birth cohort. We hypothesize that adequate maternal folate concentrations can reduce the risk of elevated SBP in children that is associated with maternal cardiometabolic risk factors.
Methods: This study included 1290 mother-child dyads recruited at birth and followed prospectively up to age 9 years from 2003-2014 at the Boston Medical Center. Child SBP percentile was calculated according to U.S. reference data and elevated SBP was defined as SBP ≥75th percentile.
Results: When examined alone, there was no association between maternal folate concentrations and child SBP. When stratified by maternal cardiometabolic risk factors, there was a significant interaction between maternal risk factors and folate (Pinteraction=0.015) on childhood elevated SBP. Among children of mothers with any cardiometabolic risk factors, their odds of elevated SBP was 40% lower (odds ratio: 0.60, 95% confidence interval: 0.40-0.90) if their mothers had higher folate concentrations (> median) compared to below median folate levels.
Conclusions: In this high-risk U.S. minority birth cohort, sufficient maternal folate concentrations may counteract the adverse effects of maternal cardiometabolic risk factors on child SBP.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Innovations in Cardiovascular Risk Assessment and Reduction
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1235-051
- 2017 American College of Cardiology Foundation