Author + information
- Indre Ceponienea,b,
- Samar El Khoudarya,b,
- Dong Lia,b,
- James Steina,b,
- Nathan Wonga,b,
- Rine Nakanishia,b,
- Negin Nezarata,b,
- Mitsuru Kanisawaa,b,
- Sina Rahmania,b,
- Kazuhiro Osawaa,b,
- Matthew Tattersalla,b and
- Matthew Budoffa,b
Background: Cardiovascular risk prediction scores do not fully explain cardiovascular (CV) risk. We aimed to evaluate the performance of ion mobility derived lipoprotein particle measures in determining the association of low density lipoprotein (LDL-P) and high density lipoprotein (HDL-P) particles with progression of coronary calcium and carotid wall injury.
Methods: All subjects in the Multi-Ethnic Study Atherosclerosis (MESA), who had ion mobility testing performed, and had coronary artery calcium score (CAC), carotid intima-media thickness (IMT) and carotid plaque data available at baseline (Exam 1) and follow up (Exam 5), were included in the study (n=2,510). CAC progression was annualized and treated as a continuous or a categorical variable (0 or regression, 0-100, 100-200, 200-300, and >300). Carotid plaque progression was treated as a continuous variable ranging from 0 to 12. One-way ANOVA was used for comparison between categories. Univariate and multivariate linear regression analyses were performed. Final models were adjusted for CV risk factors, LDL cholesterol (C), HDL-C and triglycerides.
Results: Mean (SD) follow-up duration was 9.6 (0.6) years. In both univariate and multivariate analysis, progression of CAC was significantly associated with medium and very small LDL-P (p=0.03 and p=0.01, respectively), and large HDL-P (p=0.02, all for multivariate analyses). All LDL-P categories (very small to large) and large HDL-P were significantly associated with annualized CAC progression, however, after adjustment for multiple risk factors and traditional lipids, only the association with medium and very small LDL-P remained significant. Carotid plaque score progression was significantly associated with medium, small and very small LDL-P (p<0.01 for all) and non-HDL-P (p=0.013), of which only the association with very small LDL-P remained significant after multiple adjustment (p=0.035). Mean IMT progression was not associated with any of the lipid particles.
Conclusions: In the MESA cohort, ion mobility measured LDL-P were significantly associated with CAC and carotid plaque progression beyond the effect of traditional lipids (LDL-C, HDL-C, and triglycerides).
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Innovations in Cardiovascular Risk Assessment and Reduction
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1235-058
- 2017 American College of Cardiology Foundation