Author + information
- Arwa Younis,
- Ilan Goldenberg,
- Boaz Tzur,
- Anna Mazu,
- Anan Younis,
- Zvi Fisman,
- Alexander Tannenbaum and
- Robert Klempfner
Background: Explore the association of metabolic syndrome (MetS) vs. its individual component, with 20-year all-cause mortality among patients with stable coronary artery disease (SCAD).
Methods: the cohort comprised 12,403 non-diabetic patients with SCAD who were enrolled in the Bezafibrate Infarction Prevention registry between 1990-1992, followed-up for through 2014. Study cohort was divided into four groups: patients without MetS or IFG, with IFG but without MetS, with MetS but without IFG, and with both MetS and IFG.
Results: Kaplan-Meier survival analysis (figure-1) showed that at 20 years of follow-up, all-cause mortality rates were the highest among patients with both MetS and IFG (66%). Patients with IFG without MetS experienced a significantly higher mortality rate compared to those with MetS without IFG (61% vs. 56%, respectively; log rank P <0·001). Multivariate analysis showed that, compared to patients without MetS or IFG, the risk for long-term mortality was significantly higher among those with both IFG and MetS (HR 1·31; 95%CI 1.21-1.42; p-value <0.001) and among those with IFG without MetS (HR 1.15; 95%CI 1·01-1·31; p-value=0-03). In contrast, MetS patients without IFG did not experience a statistically significant increased risk (HR 1·08; 95% CI 0·98-1·20; p-value=0·11).
Conclusions: Our findings suggest that IFG alone is a more powerful independent predictor of long-term mortality among SCAD patients than other components of the MetS.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Diabetes and Other Issues in Cardiovascular Prevention
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1277-047
- 2017 American College of Cardiology Foundation