Author + information
- Christoph H. Saely,
- Daniela Zanolin,
- Alexander Vonbank,
- Andreas Leiherer,
- Philipp Rein and
- Heinz Drexel
Background: Both coronary artery disease (CAD) and non-alcoholic fatty liver disease (NAFLD) are associated with type 2 diabetes. Whether NAFLD predicts future diabetes in CAD patients who do not have diabetes yet is unknown.
Methods: We therefore prospectively recorded diabetes incidence in a large cohort of 1018 consecutive non-diabetic patients with angiographically proven CAD; for the diagnosis of NAFLD we used the validated fatty liver index (FLI); diabetes was diagnosed according to ADA criteria.
Results: At baseline, 44.3% of our patients had impaired fasting glucose (IFG) and 55.2% had an HbA1c of 5.7-6.4% and thus were at risk of diabetes according to ADA categories. The prevalence of NAFLD was significantly higher in patients with IFG than in those with normal fasting glucose (46.8 vs. 34.0%; p<0.001) but not between patients with an HbA1c of 5.7-6.4% and those with an HbA1c <5.7% (40.8 % vs. 38.5 %; p=0.478). Prospectively, 11.2% of our patients newly developed diabetes during a follow-up period of 6.3±3.7 years; both IFG (OR 3.24 [2.03-3.32]; p=0.001) and an Hba1c of 5.7-6.4% (OR 2.90 [1.50-5.61]; p=0.002) significantly predicted incident diabetes. Importantly, diabetes incidence was significantly higher in patients with NAFLD than in those who did not have NAFLD (18.4 vs. 8.5 %; p<0.001), and NAFLD strongly predicted incident diabetes both univariately (OR 2.41 [1.56-3.73]; p<0.001) and after multivariate adjustment including both baseline fasting glucose and HbA1c (OR 1.76 [1.11-2.79]; p=0.017).
Conclusions: We conclude that NAFLD in patients with CAD strongly predicts incident diabetes independently from the baseline glycemic state.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Diabetes and Other Issues in Cardiovascular Prevention
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1277-051
- 2017 American College of Cardiology Foundation