Author + information
- Christoph H. Saely,
- Alexander Vonbank,
- Daniela Zanolin,
- Andreas Leiherer,
- Philipp Rein and
- Heinz Drexel
Background: Obesity is a major risk factor for the metabolic syndrome (MetS), but some obese individuals do not have the MetS while others have the MetS but are non-obese. We prospectively investigated the single and joint effects of obesity and of the MetS on diabetes incidence in patients with angiographically proven coronary artery disease (CAD).
Methods: Diabetes incidence was recorded over 6.1±3.7 years in a large cohort of 1063 patients with angiographically proven CAD. Obesity was defined as a BMI ≥30kg/m2; presence of the MetS was defined according to the harmonized consensus definition.
Results: From our patients, 698 were non-obese and did not have the MetS, 62 were obese but did not have the MetS, 184 were non-obese but had the MetS, and 119 were obese and had MetS. During follow-up, the overall incidence of diabetes was 12.1%, corresponding to 1.9% per year. Diabetes incidence was 6.7% in non-obese patients without the MetS. It was significantly higher in obese patients without the MetS (16.0%; p<0.001), in non-obese patients with the MetS (22.3%; p=0.009), and in obese patients with the MetS (24.4%; p<0.001). Diabetes incidence however did not differ significantly between obese or non-obese MetS patients (p=0.303) or between obese patients with and obese patients without the MetS (p=0.674).
Conclusions: We conclude that the incidence of diabetes in patients with CAD is high, except among subjects who neither are obese nor have the MetS. Both obesity and the MetS increase diabetes risk; a metabolically healthy obese phenotype does not protect against the development of diabetes in this population.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Diabetes and Other Issues in Cardiovascular Prevention
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1277-052
- 2017 American College of Cardiology Foundation