Author + information
- Angela Su-Mei Koha,b,
- Wan Yi Yewa,b,
- Xiaodan Zhaoa,b,
- Liang Zhonga,b,
- Louis Ly Teoa,b,
- Serene Chuaa,b,
- Yi Ying Hana,b,
- Jia Ing Wonga,b,
- Feiqiong Huanga,b,
- Si Yi Leea,b,
- Fei Gaoa,b,
- Woon-Puay Koha,b and
- Ru-San Tana,b
Background: Using standard definitions of adiposity such as body-mass index (BMI), previous studies of high-risk cohorts that include subjects with heart failure or diabetes mellitus suggest higher risk of cardiovascular events in sarcopenia and obesity. These prior investigations have not included general community cohorts without prevalent cardiovascular disease or cancer, and have not elucidated possible links between adverse alterations in cardiovascular structure with other measures of leanness.
Methods: From a community cohort of men and women without CV disease, stroke or cancer, we assessed cardiac remodeling by cardiac magnetic resonance imaging (MRI) (left ventricular (LV) concentricity0.67 (mass/end-diastolic volume0.67) and sarcopenia defined by European Working Group on Sarcopenia in Older People (EWGSOP) (appendicular lean mass, ALM/height2), in conjunction with standard measures of adiposity using detailed body composition analyzer.
Results: We examined 165 subjects (65 females (39%), mean age 73±4 years, 93 (56%) hypertensive with mean LV ejection fraction 66±8. There were significant correlations between BMI- (r=0.179, p=0.022), weight- (r=0.324, p<0.0001), WHR- (r=0.174, p=0.032), skeletal muscle mass- (r=0.360, p<0.0001), ALM/height2 -(r=0.276, p=0.001), and concentricity. By regression analyses, both WHR (β=1.801, SE 0.744, p=0.017), and ALM/height2 (β=0.130, SE 0.05, p=0.01) independently predicted concentricity. BMI, hypertension status and age were not independently associated with concentricity.
Conclusions: We provide interesting preliminary data that show relationships between cardiac remodeling and measures of adiposity and leanness. The finding that both WHR (a measure of abdominal adiposity) and appendicular leanness are factors associated with cardiac remodeling in a community cohort should stimulate further studies to interrogate both fatness and leanness with cardiovascular risk.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Diabetes and Other Issues in Cardiovascular Prevention
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1277-056
- 2017 American College of Cardiology Foundation