Author + information
- Francesco Baratta,
- Daniele Pastori,
- Licia Polimeni,
- Ilaria Ernesti,
- Francesco Violi,
- Maria Del Ben and
- Francesco Angelico
Background: Many genetic, epigenetic and environmental mechanisms play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). NAFLD is strongly associated with obesity and diabetes. So far, no effective treatment for the prevention and management of NAFLD are available. Several nutritional approaches have proposed for NAFLD patients. The Mediterranean Diet (MD) is a dietary pattern with beneficial properties in primary and secondary prevention of cardio-metabolic diseases.
Aim of the study is to investigate the relationship between MD and NAFLD in a cohort of consecutive metabolic patients and to investigate how MD adherence affects metabolic phenotype in NAFLD patients.
Methods: 584 consecutive patients underwent ultrasonography to assess the presence of fatty liver, using Hamagouchi's criteria. Adherence to the MD was investigated by the administration of a short dietary questionnaire, elaborated by Martinez-Gonzalez et al (2004). For the analysis patients were divided in two groups according to the MD score: low adherence (0-5 points), and high adherence (6-9 points).
Results: Mean age was 56.1±12.8 years, 38,2% were women. According to the MD score, 227 patients (38.9%) had low, and 357 had a good adherence to MD (61.1%). Overall, the prevalence of NAFLD was 82,6%. NAFLD was significantly higher in the poor adherence group (88.5% vs 79,0%; p=0.003). Thus, MD score was significantly lower in patients with NAFLD compared to those without [6 (4/7) vs 5 (4/6); p<0,001]
Among 483 NAFLD patients, at univariate analysis, MD questionnaire score was positively correlated with age (Rs=0.135; p=0.003), while was inversely correlated with triglycerides (Rs=-0,106; p=0.023), fatty liver index (Rs=-0,163; p<0,001), lipid accumulation product (Rs=-0,135; p=-0,002), Homa-IR (Rs=-0,127; p=0.009) and BMI (Rs=-0.101; p=0.027).
Conclusions: We found that adherence to MD is associated with a lower prevalence of NAFLD. Moreover, NAFLD patients with a good adherence to MD disclose a better metabolic profile. Our findings suggest that MD could be considered the optimal diet to obtain the weight loss recommended by guidelines as first-line intervention in NAFLD treatment.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Diabetes and Other Issues in Cardiovascular Prevention
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1277-064
- 2017 American College of Cardiology Foundation