Author + information
- Bin Yang,
- Tufik R. Assad,
- Reid D'Amico,
- Stephen J. Halliday,
- Meng Xu,
- Eric Farber-Eger,
- Quinn S. Wells and
- Evan L. Brittain
Background: It is unknown whether racial differences exist among pulmonary hypertension (PH) patients. We investigated the associations between race and PH in patients referred for right heart catheterization (RHC).
Methods: We extracted data for African-American (AA) and Caucasian patients undergoing RHC from 1998-2014 at Vanderbilt. PH was categorized as pulmonary arterial hypertension (PAH), isolated post-capillary PH (Ipc-PH), or combined pre- and post-capillary PH (Cpc-PH) according to consensus guidelines.
Results: A total of 4,583 patients were analyzed, including 587 AAs (13%) and 3,996 Caucasians (87%). Despite younger age (53±14 vs 61±15; p<0.001), AAs had a higher prevalence of cardiac disease, metabolic syndrome, and PH (73% vs 57%; p<0.001) than Caucasians (Table). In 2,693 patients with PH, pulmonary vascular disease was more severe in AAs (Table). After adjusting for age, sex, diabetes, heart failure, body mass index, hypoxic lung disease, and creatinine, AA race was independently associated with PH (OR 1.50, 95%CI 1.22-1.85; p<0.001) and Cpc-PH (OR 1.51, 95%CI 1.13-2.02; p=0.005), but not PAH (p=0.05) or Ipc-PH (p=0.64). AA race was not associated with increased adjusted mortality (p=0.92).
Conclusion: AA patients referred for RHC had more advanced cardiac, metabolic, and pulmonary vascular disease despite being younger than Caucasians. AA race was independently associated with PH and Cpc-PH. Further studies are warranted to examine racial differences in the development of PH.
Room 147 B
Saturday, March 18, 2017, 8:38 a.m.-8:48 a.m.
Session Title: Highlighted Original Research: Pulmonary Hypertension and Venous Thrombo-embolic Disease and the Year in Review
Abstract Category: 35. Pulmonary Hypertension and Pulmonary Thrombo-embolic Disease
Presentation Number: 904-08
- 2017 American College of Cardiology Foundation