Author + information
- Masataka Sugahara,
- Keiko Ryo-Koriyama,
- Akiko Goda,
- Omar Batal,
- Marc Simon and
- John Gorcsan
Background: Pulmonary hypertension (PH) is a progressive disease which results in right-sided pressure and volume overload. Right ventricular (RV) and atrial (RA) remodeling play a critical role in the prognosis of patients with PH. Our aim was test the hypothesis that the simple echo measures of RV and RA morphology have prognostic value in patients with PH.
Methods: We studied 144 patients with pre-capillary PH confirmed by invasive hemodynamics. They were aged, 57±15 years; 72% women: 84 (58%) had idiopathic PH, 55 (38%) had collagen vascular disease, and 5 (3%) were others. Echo prognostic markers studied were echocardiographic RV end systolic area (RVESA) and right atrial area (RAA) from the 4-chamber view. Polynominal regression analysis of invasive hemodynamics and echo showed a significant association of decline in peak RV stroke work index (19.3 cJ) with 23.4 cm2 of RV end-systolic area (RVESA) (p=0.023). Outcome was predefined as all-cause mortality over 2 years.
Results: In 144 PH patients, RA area was positively correlated with mean RA pressure (p<0.001). Adverse-remodeled RV (RVESA > 23.4cm2) and RA dilatation (RA area > 18cm2) in PH were significantly associated with survival (p=0.024, Chi-square 7.48).
Conclusion: The combination RV and RA remodeling by simplified echocardiographic measures were associated with all-cause mortality in patients with PH and have prognostic utility.
Room 147 B
Saturday, March 18, 2017, 8:51 a.m.-9:01 a.m.
Session Title: Highlighted Original Research: Pulmonary Hypertension and Venous Thrombo-embolic Disease and the Year in Review
Abstract Category: 35. Pulmonary Hypertension and Pulmonary Thrombo-embolic Disease
Presentation Number: 904-10
- 2017 American College of Cardiology Foundation