Author + information
- Yalin Yaylalia,b,
- Emine Kilic-Topraka,b,
- Yusuf Ekbica,b,
- Yasin Ozdemira,b,
- Vural Kucukataya,b,
- Hande Senola,b,
- Nese Dursunoglua,b and
- Melek Bor-Kucukataya,b
Background: Understanding of the pathophysiological manifestations of pulmonary arterial hypertension (PAH) is still evolving. The aim of the study was to determine alterations in blood rheology and oxidative stress parameters in PAH.
Methods: The study included 27 treatment-naive patients with PAH and 35 age and sex-matched healthy controls. The 6-minute hall walk was performed. Patients were in class II (n=10), class III (n=16), and class IV (n=1). All participants underwent a right-heart catheterization to confirm the diagnosis and to assess hemodynamics. Erythrocyte deformability and aggregation were measured by an ektacytometer. Oxidative stress parameters were measured using a commercial kit.
Results: The average pulmonary vascular resistance was 5.41±3.12 WU, mean right atrial pressure was 9.78±5.35 mmHg, cardiac index was 4.00±2.37 l/min/m2, mixed venous O2 saturation was 67.42±12.44%, and six-minute walk distance was 328.28±138.22 m. Erythrocyte deformability measured at 0.53-30.00 Pa were significantly lower in patients with PAH. Erythrocyte aggregation index (AI) and total antioxidant status were significantly higher in patients with PAH.
Conclusion: The hemorheological alterations observed (increased erythrocyte aggregation and decreased erythrocyte deformability) could theoretically increase the flow resistance through the pulmonary vascular system and could be of hemodynamic significance.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Advances in Pulmonary Arterial Hypertension
Abstract Category: 35. Pulmonary Hypertension and Pulmonary Thrombo-embolic Disease
Presentation Number: 1269-004
- 2017 American College of Cardiology Foundation