Author + information
- Christoffer Goransson,
- Niels Vejlstrup and
- Jorn Carlsen
Background: Ergometer exercise in healthy normals leads to decreased left and right ventricular volumes and increased stroke volume. In pulmonary arterial hypertension (PAH) stroke volume is constant during ergometer exercise, while changes in ventricular volumes are not fully described. This study evaluates ventricular volumes during physiologic stress in patients with PAH.
Methods: Left and right ventricular end diastolic volumes (LVEDV and RVEDV) and end systolic volumes (LVESV and RVESV), stroke volume and cardiac output were measured in nine patients with PAH using cardiovascular magnetic resonance imaging at rest and during ergometer stress. Resting volumes were measured during breath hold with cine and exercise volumes were measured during free-breathing with cine set to four averages. Stroke volume and cardiac output was measured by aortic flow. Patients were to achieve 13/20 on the Borg Rating of Perceived Exertion Scale.
Results: During exercise, cardiac output increased by 64% (p<0.0001) but stroke volume was unaltered (p=0.27). Exercise dilated the right ventricle (RVEDV by 10%, RVESV by 11%) and compressed the left ventricle (LVEDV by 9%, LVESV by 18%). Se figure.
Conclusions: Exercise in PAH induces right ventricular dilatation and compression of the left ventricle. Right ventricular response in PAH to exercise is in contrast to reported healthy controls. Favorable exercise response to therapy in PAH should theoretically reduce right ventricular volume and increase stroke volume.
Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-10:30 a.m.
Session Title: Advances in Pulmonary Arterial Hypertension
Abstract Category: 35. Pulmonary Hypertension and Pulmonary Thrombo-embolic Disease
Presentation Number: 1269-007
- 2017 American College of Cardiology Foundation