Author + information
- Lauge Østergaard,
- Nana Valeur Køber,
- Lars Køber,
- Nikolaj Ihlemann,
- Henning Bundgaard,
- Gunnar Gislason,
- Christian Torp-Pedersen,
- Niels Eske Bruun and
- Emil Loldrup Fosbøl
Background: Patients undergoing aortic valve replacement (AVR) are at risk of developing infective endocarditis (IE) and this risk may be influenced further by the presence of a pacemaker. We examined how concomitant pacemaker influenced longitudinal risk of IE in a nationwide cohort of patients undergoing AVR.
Methods: Using Danish nationwide registries we included all patients who were discharged after undergoing AVR in Denmark from Jan 1996 – Dec 2012. Patients were followed until death, end of study period (31st December 2012), or admission to hospital due to IE, whichever came first. We excluded patients with previous or current IE. Cumulative incidence plot was drawn for time to IE accounting for death as a competing risk. The incidence of IE between groups were analyzed using multivariable adjusted Cox proportional hazard analysis.
Results: We included 13,454 AVR patients; 401 patients (3.0%) with a pacemaker (70.6% male, median age 75.2 years, IQR: 68.8-79.4 years) and 13,053 patients (97.0%) with no pacemaker (63.6% male, median age: 71.3 years, IQR: 63.3-77.1 years). Relative to no pacemaker, concomitant pacemaker was associated with an increased incidence of IE (Figure) and this held true in the multivariable adjusted analysis: hazard ratio=1.92, 95% CI: 1.26-2.94.
Conclusions: In patients undergoing aortic valve replacement, a concomitant pacemaker was associated with twice the incidence of IE.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Valvular Heart Disease: Endocarditis
Abstract Category: 36. Valvular Heart Disease: Clinical
Presentation Number: 1103-025
- 2017 American College of Cardiology Foundation