Author + information
- Carlos José Dornas Gonçalves Barbosa,
- Renata Barreiros,
- Andre Franci,
- Remo Furtado,
- Flavia Arantes,
- Célia Strunz,
- Rocha Tania,
- Jose Antonio F. Ramires,
- Roberto Kalil-Filho and
- Jose Nicolau
Background: Approximately 17% of pts with coronary artery disease (CAD) have previous ischemic stroke or transitory ischemic attack. (IS/TIA). This is a high risk subgroup for ischemic and bleeding events. The role of platelet aggregability, coagulation, endogenous fibrinolysis and inflammation in this population is uncertain.
Methods: 1:1 case-control study (70 pts with IS/TIA, Case Group; 70 pts without previous IS/TIA, Control Group). The main inclusion criteria were a previous episode of acute coronary syndrome (ACS) at least 12 months before inclusion in the study and chronic aspirin use. Main exclusion criteria included use of dual antiplatelet therapy, and known hemorrhagic stroke, severe renal dysfunction, thrombocytopenia or coagulopathy. Pts were matched by sex, age, type and year of occurrence of ACS. Thromboxane A2 and P2Y12 paths were analyzed for platelet aggregability; adittionaly, the following tests were developed: Reorox and fibrinogen for coagulation, D-dimer and plasminogen activation inhibitor- 1 (PAI-1) for fibrinolysis, Interleukin-6 (IL-6) and ultrasensitive C-reactive protein ultrasensitive (CRP-us) for inflammation.
Results: The main results are depicted in the following Table.
Conclusions: The higher risk for ischemic and bleeding events in patients with previous IS/TIA, could not be explained by the tests of platelet aggregability, coagulation, endogenous fibrinolysis and inflammation analyzed in the present study.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Emerging Basic Science in Ischemic Heart Disease
Abstract Category: 1. Acute and Stable Ischemic Heart Disease: Basic
Presentation Number: 1251-300
- 2017 American College of Cardiology Foundation