Author + information
- Christine Parsonsa,b,
- Stephen Chaa,b,
- Win-Kuang Shena,b,
- Santosh Desaia,b,
- Salma Patela,b,
- Alanna Chamberlaina,b,
- Sushil Allen Luisa,b,
- Maria Aguilara,b,
- Bart Demaerschalka,b,
- Farouk Mookadama,b and
- Fadi Shamouna,b
Background: Research is conflicting whether kidney function should be incorporated in thromboembolism risk prediction. Our recent study showed that the CHA2DS2-VASc score predicts thromboembolism and mortality in those without atrial fibrillation. We evaluate if the addition of renal impairment is predictive.
Methods: We used the Rochester Epidemiology Project medical records system from 1/10/04 – 3/7/16 to retrospectively evaluate whether adding renal impairment (1 point) to the CHA2DS2-VASc score (-R) predicts mortality, thromboembolism, and atrial fibrillation in patients without atrial fibrillation. Score groupings were chosen based on similar hazard ratios (HR). Renal impairment was defined as chronic kidney disease stage III or greater. An implantable device was required to discern the absence of atrial fibrillation.
Results: The population (n=1,606) had a mean age of 69.8 years and median follow-up of 4.8 years. Mortality, thromboembolism, and incident atrial fibrillation correlated significantly with increasing CHA2DS2-VASc-R score (Figure 1). Baseline renal impairment was predictive of mortality (HR 2.06, 95% confidence interval (CI) 1.64-2.60, p<0.001), thromboembolism (HR 1.34, 95% CI 0.96-1.87, p=0.09), and atrial fibrillation (HR 1.31, 95% CI 0.98-1.74, p=0.07).
Conclusions: Adding renal impairment to the CHA2DS2-VASc score predicts mortality and there is a trend towards predicting atrial fibrillation and thromboembolism in a population without atrial fibrillation.
Moderated Poster Contributions
Vascular Medicine Moderated Poster Theater, Poster Hall, Hall C
Friday, March 17, 2017, 11:15 a.m.-11:25 a.m.
Session Title: Highlights in Vascular Medicine Research
Abstract Category: 38. Vascular Medicine: Basic
Presentation Number: 1139M-13
- 2017 American College of Cardiology Foundation