Author + information
- Purushothaman K-Raman,
- Meerarani Purushothaman,
- Baber Usman,
- Arthur Tarricone,
- Miguel Vasquez,
- Annapoorna Kini,
- Samin Sharma,
- Pedro Moreno and
- Prakash Krishnan
Background: Paclitaxel Drug Coated Balloon (PDCB) inhibits cellular proliferation leading to reduction in neointimal expansion compared to Plain Old Balloon Angioplasty (POBA). Our study sought to investigate the morphological features of atherectomy plaques derived from PDCB and POBA in peripheral artery disease.
Methods: Randomly selected peripheral atherectomy plaques from five patients at baseline and restenosis of same patients in PDCB, were compared with plaques procured at baseline and restenosis from the same patients in POBA. Plaques were evaluated for neointima thickness (H&E), smooth muscle cells (smcs-α-actin), fibroblasts (FSP-1), cell proliferation index (Ki67) by immunohistochemistry and graded.
Results: PDCB restenosis using paclitaxel therapy showed delta values (difference between first and second intervention) by significant reduction in neointima thickness, smcs, fibroblast density and Ki67 percentage compared to POBA. (<p=0.05 for all comparison; Figure).
Conclusions: Our study demonstrates morphological features in PDCB suggests a significant reduction in the neointima, smcs and fibroblasts compared to POBA. PDCB intervention may reduce neointima proliferation and thus may minimize the incidence of restenosis.
Moderated Poster Contributions
Vascular Medicine Moderated Poster Theater, Poster Hall, Hall C
Friday, March 17, 2017, 11:30 a.m.-11:40 a.m.
Session Title: Highlights in Vascular Medicine Research
Abstract Category: 39. Vascular Medicine: Endovascular Therapy
Presentation Number: 1139M-15
- 2017 American College of Cardiology Foundation