Author + information
- Vladimir Lakhter,
- Chad Zack,
- Satyajit Reddy,
- Saurav Chatterjee,
- Vikas Aggarwal,
- Paul Katz and
- Riyaz Bashir
Background: Although acute intracranial hemorrhage (ICH) is a rare complication of catheter directed thrombolysis (CDT), it remains a major concern associated with the use of this therapy. The incidence and clinical predictors of developing ICH in the setting of CDT are not known.
Methods: The Nationwide Inpatient Sample (NIS) database was used to identify all patients who underwent CDT for the treatment of proximal LE or caval DVT between January 2005 and December 2013 in the United States (US). Multivariate logistic regression was used to identify the clinical predictors of developing ICH among patients treated with CDT.
Results: Among 141,258 patients with the principal discharge diagnoses of proximal LE or caval DVT, 7398 (5.2%) patients were treated with CDT. A total of 52 patients developed ICH during the study period (0.7% of all CDT patients). Independent predictors of ICH included male gender (OR 1.8, 95% CI 1.02 – 3.3, p = 0.04), coagulopathy (OR 2.0, 95% CI 0.99 – 3.9, 0.05, p = 0.05), age 51-74 years (OR 2.1, 95% CI 0.99 – 4.5, p = 0.05), chronic kidney disease (CKD): (OR 2.5, 95% CI 1.2 – 5.1, p = 0.02), age over 75 years (OR 4.1, 95% CI 1.7 -9.7, p < 0.01), and history of stroke (OR 14.7, 95% CI 7.1 – 30.8, p < 0.01), (Figure 1).
Conclusions: This nationwide observational study showed that ICH rates are very low in patients undergoing CDT. The patients at highest risk of ICH include those with history of stroke, CKD, age greater than 75 years. Interestingly, ICH rates were noted to be more common in men than in women.
Moderated Poster Contributions
Vascular Medicine Moderated Poster Theater, Poster Hall, Hall C
Saturday, March 18, 2017, 10:15 a.m.-10:25 a.m.
Session Title: Advances in Pathophysiology and Treatment of Thrombosis
Abstract Category: 41. Vascular Medicine: Venous Disease
Presentation Number: 1218M-07
- 2017 American College of Cardiology Foundation