Author + information
- Bo Hu,
- Nan Jiang,
- Qing Zhou,
- Jin-Ling Chen,
- Sheng Cao,
- Jing-Jing Cui and
- Rui-Qiang Guo
Background: The key of acute myocardial infarction therapy is to eliminate coronary micro-circulation thrombus. However, effective thrombolysis in micro-circulation was still unsolved. Therefore, we sought to explore novel method with dodecafluoropentane (DDFP) acoustic vaporizable nano-droplet for coronary micro-circulation thrombolysis.
Methods: The cavitation stability and efficiency of the nano-droplets (group A) for thrombolysis were tested in an in-vitro vascular system (Fig 1A, 1B) with thrombus occlusion, comparing with microbubbles (group B) and PBS buffer solution as control (group C). Group A, B and C were pumped into the system with ultrasound irradiation for thrombolysis process. Thrombus weight loss was compared after thrombolysis.
Results: The size of nano-droplets was 424.7± 30.2nm with more than 75% ranged from 300-750nm. The fluorescence microscope showed the nano-droplets were uniform-shaped, stable-structured with favorable dispersity and gradually turned into microbubbles by ultrasound irradiation (from Fig 1C, 1D to 1E). The thrombolysis rates in group A (32.1±4.4%) was significantly larger than those in group B (12.7±2.8%) and C (5.0±2.4%) (p<0.05). Also, stable cavitation effect was successfully produced in group A for lasting more than 60s while failed in group B and C.
Conclusions: DDFP vaporizable nano-droplet with ultrasound irradiation was effective for thrombus elimination in coronary micro-circulation through lasting and stable cavitation effect.
Poster Hall, Hall C
Saturday, March 18, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Emerging Basic Science in Ischemic Heart Disease
Abstract Category: 1. Acute and Stable Ischemic Heart Disease: Basic
Presentation Number: 1251-302
- 2017 American College of Cardiology Foundation