Author + information
- Vasiliki Tsigkou,
- Gerasimos Siasos,
- Evangelos Oikonomou,
- Konstantinos Mourouzis,
- George-Angelo Papamikroulis,
- Eleni Kokkou,
- Georgia Vogiatzi,
- Nikolaos Gouliopoulos,
- Sotirios Tsalamandris,
- Nikolaos Papageorgiou,
- Savvas Mazaris,
- Manolis Vavuranakis,
- Christodoulos I. Stefanadis and
- Dimitris Tousoulis
Background: Smoking is a major cardiovascular risk factor and is associated with vascular dysfunction. Natural Chios Mastic (NCM), a rich source of flavonoids, exerts numerous beneficial effects in patients with metabolic syndrome and dyslipidemia. We investigated the effects of short-term NCM supplementation on endothelial function and arterial stiffness in healthy young smokers.
Methods: We studied the effect of a 4-week treatment with NCM caps (2g per day) in 14 healthy young smokers (24±5 years) on two occasions (day 0: baseline and day 28) in a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before (pSm) and 20 minutes (Sm20) after cigarette smoking (standard cigarette: 1.1 mg nicotine, 12 mg tar). Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness.
Results: Cigarette smoking decreased FMD and increased PWV 20 minutes after cigarette smoking (Sm20) in both day 0 (FMD: from 5.95±4.11% pSm to 4.54±3.55% in Sm20, p=0.001; PWV: from 5.90±0.59m/sec pSm to 6.21±0.74m/sec in Sm20, p=0.05) and day 28 (FMD: from 7.78±3.53% pSm to 5.71±3.29% in Sm20, p=0.001; PWV: from 5.84±0.71m/sec pSm to 6.32±0.69m/sec in Sm20, p=0.005). Interestingly, NCM increased baseline pSm values of FMD (Day 0: 5.95±4.11%, Day 28: 9.52±2.74%, p=0.04) and decreased baseline pSm values of PWV (Day 0: 5.90±0.74m/sec to 5.70±0.64m/sec, p=0.03) (Figure). Finally, placebo administration did not affect baseline pSm values of FMD and PWV (p=NS for both).
Conclusions: Short-term supplementation of NCM improved endothelial function and arterial stiffness in healthy young smokers. These findings suggest that NCM flavonoids may inhibit the detrimental effects of smoking on vascular endothelium and arterial wall and provide new means to restore arterial wall properties in high risk subjects.
Moderated Poster Contributions
Vascular Medicine Moderated Poster Theater, Poster Hall, Hall C
Saturday, March 18, 2017, 1:00 p.m.-1:10 p.m.
Session Title: Uncovering the Intricacies of Vascular Function
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1228M-07
- 2017 American College of Cardiology Foundation