Author + information
- Leticia Fernandez-Friera,
- Lopez-Melgar Beatriz,
- Belen Oliva,
- Agustin Mocoroa,
- Jose Maria Mendiguren,
- Stuart Pocock,
- Borja Ibañez,
- Jose Manuel Garcia-Ruiz,
- Antonio Fernandez-Ortiz,
- Javier Sanz and
- Valentin Fuster
Background: Absence of cardiovascular risk factors (RF) is considered low risk for atherosclerosis. Our aim was to identify determinants of subclinical atherosclerosis in the absence of RF and explore the impact of upper normal ranges (pre-RF).
Methods: Participants with normal values of RF from the PESA study were included (n=1769, 45 y, 50% male), defined as untreated SBP/DBP <140/90 mmHg, glucose <126 mg/dL, total cholesterol, LDL-C and HDL-C of <240, <160, ≥40 mg/ml and not smoking. Ultrasound-based plaque of the carotid, aorta and ilio-femoral arteries, coronary artery calcification (CAC) and serum biomarkers were evaluated. Within the normal values of RF, pre-RF was also assessed as prehypercholesterolemia (cholesterol 200-239 mg/ml), prediabetes (HbA1c 5.7-6.4% or glucose 100-125 mg/ml) and prehypertension (SBP/DBP 130-139/85-89 mmHg).
Results: In individuals with normal values of RF, plaque or CAC was present in 49.8%, with ≥2 sites affected in 27.2%. In multivariable analyses, male (OR 2.19; 1.8-2.68), HbA1c (OR1.76; 1.33-2.32), vascular cell adhesion molecule (VCAM; OR 1.16; 1.06-1.27), age (OR 1.14; 1.11-1.16), LDL-C (OR 1.13; 1.08-1.18), and cystatin (OR 0.19; 0.07-0.49) were significantly associated with atherosclerosis. The number of territories with atherosclerosis increased with the pre-RF burden (Fig).
Conclusions: Atherosclerosis burden increased with the number of pre-RF and was independently associated with male, age, LDL-C, HbA1c, VCAM and cystatin in the absence of RF.
Moderated Poster Contributions
Vascular Medicine Moderated Poster Theater, Poster Hall, Hall C
Sunday, March 19, 2017, 9:45 a.m.-9:55 a.m.
Session Title: Improving Risk Assessment in Atherosclerosis
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1310M-03
- 2017 American College of Cardiology Foundation