Author + information
- Sushan Yang,
- Shi Huang,
- Joseph Yeboah,
- Lori Daniels,
- Joao Lima,
- Joshua Beckman,
- John Carr,
- Thomas Wang and
- Deepak Gupta
Background: Natriuretic peptides (NP) are cardiac-derived hormones that promote vasodilation, natriuresis, and diuresis. Circulating NP levels are lower in black compared with white individuals, but the pathophysiologic consequences of lower NP levels are not well understood. We hypothesized that lower NP levels are associated with worse endothelial function.
Methods: In 1,577 Multi-Ethnic Study of Atherosclerosis participants (63% white, 37% black) without prevalent cardiovascular disease at baseline (2000-2002), multivariable linear regression models adjusted for traditional cardiovascular risk factors, anti-hypertensive medication use, and baseline brachial artery diameter were used to examine the association between serum N-terminal pro B-type NP (NT-proBNP) and flow-mediated dilation (FMD).
Results: Black participants had lower FMD (median 3.1%; IQR 1.6-4.8) compared with whites (4.2%; 2.5-6.4), p<0.001. In multivariable models, the difference in FMD between black and white participants was partially attenuated by NT-proBNP. Further, the association between NT-proBNP and FMD differed by race, interaction p=0.007. Among blacks, NT-proBNP was significantly positively associated with FMD (β=0.3; 95% CI: 0.1-0.5, p=0.001) (Figure). In contrast, NT-proBNP levels were not associated with FMD in white participants (β=-0.009, 95% CI: -0.2 – 0.2, p=0.92).
Conclusions: Lower NP levels may account, in part, for worse endothelial function in black compared with white individuals.
Moderated Poster Contributions
Vascular Medicine Moderated Poster Theater, Poster Hall, Hall C
Sunday, March 19, 2017, 10:15 a.m.-10:25 a.m.
Session Title: Improving Risk Assessment in Atherosclerosis
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1310M-07
- 2017 American College of Cardiology Foundation