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Background: Human leukocyte antigen (HLA) is a key regulator in immune response and implicated in abdominal aortic aneurysm (AAA) development. We assessed whether a HLA risk score (RS), derived from HLA-phenotypes in genome-wide association study catalog, was associated with AAA expansion.
Methods: Study participants were from the Mayo clinic Vascular Disease Biorepository. HLA phenotypes were ascertained from electronic health records with a prevalence in patients with AAA > 1%. Feature selection was performed using logistic backward stepwise analysis, based on the Akaike information Criterion and adjusted for age, sex, smoking and family history of aortic aneurysm. Regression coefficients of HLA phenotypes for presence of AAA were used to build the RS and validated by bootstrap iteration (n =500). The association of RS with AAA expansion was assessed in 487 patients with ≥ 3 measures of pre-operation AAA size.
Results: The mean age was 68 ± 10 years, 61% were men, 1100 of 8062 patients with history of AAA. 21 of 34 HLA phenotypes were analyzed based on the inclusion criteria. 15 HLA phenotypes were associated with AAA independent of age, sex, smoking and family history after stepwise analysis (the area under curve of the model = 0.81). Derived RS of 19 variables was associated with faster AAA expansion (p = 0.01), mainly driven by non-atherosclerotic HLA phenotypes (Table).
Conclusions: A RS of HLA phenotypes was associated with faster AAA expansion, suggesting an important immune response in AAA progression.
Poster Hall, Hall C
Friday, March 17, 2017, 10:00 a.m.-10:45 a.m.
Session Title: Vascular Medicine: New Insights Into Aortic and Peripheral Artery Diseases
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1128-353
- 2017 American College of Cardiology Foundation