Author + information
- Muhammad Afzal Khan,
- Venu Pasricha,
- Steven Song,
- Mahyar Pourriahi,
- Muhammad Ihsan,
- Arismendy Nunez Garcia,
- Attiya Haque,
- Allan Bowen,
- Louis Salciccioli and
- Jason Lazar
Background: Nailfold videocapillaroscopy (NFC) is a non-invasive imaging technique that is used clinically in the rheumatology arena in order to directly visualize capillaries for the identification of microvascular abnormalities related to systemic sclerosis. More recently, this technique has been performed to assess microvascular involvement in non-rheumatic conditions such as arterial hypertension, diabetes mellitus, acromegaly, hyperthyroidism, Syndrome X. Although African Americans (AA) are particularly susceptible to hypertensive related microvascular target organ damage, NFC has not been studied in this setting. Accordingly, the objective of this study was to characterize o characterize subclinical microvascular structural abnormalities in AA with hypertension (HTN).
Methods: We studied 40 AA controls and 38 AA HTN subjects, of which 14 also had diabetes (DM). NFC was performed 3-4x on each of 8 digits using a capillaroscope and recorded digitally for off-line analysis. Images were reviewed by a blinded observer according to previously published criteria and mean capillary number and final capillary score (indirectly related to capillary number) were calculated and averaged for each subject.
Results: The HTN groups was significantly older, had higher body mass index (BMI) and higher systolic and diastolic blood pressures (all p<.002). On NFC, the mean capillary number was lower (7.1 ± 1.4 vs 7.6 ± 2.4 vs 8.8 ± 1.4, p=.003) and the final capillary score was higher in the HTN-DM and the HTN groups (.35±.48 vs 1.13 ± .95 vs 1.2 1± .70, p= <.001) as compared to controls. On multivariate linear analyses, both mean capillary number and final capillary score were independently related to HTN after adjusting for age, BMI, and mean arterial pressure (both p<.02).
Conclusions: HTN is associated with lower capillary density in AA with HTN. The relation between capillary density and other markers of target organ disease merits further study.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Vascular Medicine: Novel Risk Measures in Arterial Diseases
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1167-353
- 2017 American College of Cardiology Foundation