Author + information
- Matan Rothschilda,b,
- Ilana Schlama,b,
- Ping Wanga,b,
- Robert Hutchinsa,b,
- Robert Siska,b and
- Charles Gluecka,b
Aim: Our specific aim was to document the etiologic importance of thrombophilia among patients being evaluated for ocular vascular occlusion (OVO) including retinal vein occlusion (RVO, n=215), retinal artery occlusion (RAO, n=66), and non-arteritic anterior ischemic optic neuropathy (NAION, n =21) when compared to 110 healthy normal controls.
Methods: We evaluated familial and acquired thrombophilia in 302 patients referred for evaluation by retinologists, without typical risk factors for ocular thrombosis and/or severe ocular ischemic presentation.
Results: The 215 patients with RVO differed from normal controls for high homocysteine (41/207 [20%] vs 5/107 [5%], p=.0002), high anticardiolipin antibody (ACLA) IgM (19/204 [9%] vs 2/109 [2%], p=.016), high (>150%) Factor VIII (34/188 [18%], vs 7/103 [7%], p=.008), and low free protein S (17/186 [9%] vs 2/96 [2%], p=.025). The 66 patients with RAO differed from the 110 normal controls for high serum homocysteine (13/65 [20%] vs 5/107 [5%], p=.0035), high Factor VIII (16/64 [25%] vs 7/103 [7%], p=.002), and high (>150%) Factor XI (9/64 [14%] vs 3/101 [3%], p=.011). The 21 patients with NAION differed from the 110 normal controls by heterozygosity for the G20210A mutation of the prothrombin gene (4/19 [21%] vs 3/110 [3%], p=.0091).
Conclusions: In patients with OVO, familial and acquired thrombophilia are important etiologies. OVO is a diagnostic window for the presence of familial and acquired thrombophilia, an early warning system relevant for both ocular thrombotic events and for systemic thrombotic events.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Vascular Medicine: Novel Risk Measures in Arterial Diseases
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1167-355
- 2017 American College of Cardiology Foundation