Author + information
- Angela Su-Mei Koha,b,
- Jia Ing Wonga,b,
- Wan Yi Yewa,b,
- Serene J.M. Chuaa,b,
- Feiqiong Huanga,b,
- Shuang Lenga,b,
- Liang Zhonga,b,
- Si Yi Leea,b,
- Fei Gaoa,b,
- Ru-San Tana,b and
- Woon-Puay Koha,b
Background: The concept that muscle mass may mediate cardiovascular function among subjects with cardiovascular disease (CVD) is emerging. In the absence of CVD, whether this phenomenon is also present is unknown. The aging CV system, in tandem with age-related sarcopenia, may provide clues to expand this concept among subjects without CVD. We investigated if sarcopenia is related to subclinical vascular dysfunction among community elderly without CVD.
Methods: This was a community-based cohort study. The participants were those of mean age 72.4 years (SD 4.1) and without any self-reported history of physician-diagnosed coronary heart disease, stroke or cancer. They underwent assessment of central vascular function using applanation tonometry. Sarcopenia was diagnosed using gender-based cut-off values defined by European Working Group on Sarcopenia in Older People (EWGSOP) (appendicular lean mass, ALM/height2), measured using detailed body composition analyzer for appendicular muscle mass. We related sarcopenia to measures of arterial stiffness (carotid-femoral pulse wave velocity, CFPWV; augmentation index (AIx) using linear regression adjusting for standard risk factors.
Results: In this general population, out of 186 subjects [79 women (42.5%)], 100 subjects (53.8%) were sarcopenic. There were no age (72.6 vs 72.2 years, p=0.54), female gender (37% vs 49%, p=0.14) or risk factor differences in hypertension (50% vs 57%, p=0.38), diabetes mellitus (27% vs 15%, p=0.052), smoking history (23% vs 19%, p=0.68) among sarcopenic vs non-sarcopenic patients. Sarcopenic subjects had higher AIx compared to individuals who were not sarcopenic (AIx 31% vs 27%, p=0.028), but similar CFPWV (10.0 m/s vs 10.2 m/s, p=0.67). After multivariable adjustment, sarcopenia was positively associated with AIx (β=4.29, SE 1.41, 95%CI 1.51-7.07, p=0.003).
Conclusions: Among a community cohort of elderly subjects without CVD, sarcopenia was associated with subclinical vascular dysfunction, independent of underlying risk factors. These findings may be used to deepen mechanistic understanding between muscle mass and incident CVD.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Vascular Medicine: Novel Risk Measures in Arterial Diseases
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1167-356
- 2017 American College of Cardiology Foundation