Author + information
- Alexis S. Antonopoulos,
- Nikolaos Gouliopoulos,
- Gerasimos Siasos,
- Evangelos Oikonomou,
- Theodosia Konsola,
- Georgia Siasou,
- Manolis Vavuranakis,
- Nikolaos Tentolouris and
- Dimitris Tousoulis
Background: Arterial elastic properties and endothelial dysfunction are among the hallmarks of vascular disease. Currently there are no biomarkers that can predict the progress of microangiopathy in type 2 diabetics (T2D). We sought to examine whether arterial stiffness and endothelial dysfunction are associated with the development of new diabetic retinopathy in T2D.
Methods: A total of 80 T2D patients were screened for diabetic retinopathy. At baseline visit brachial artery flow mediated dilatation (FMD) and pulse wave velocity (PWV) were assessed as indices of endothelial function and arterial stiffness respectively. After 30 months, patients were re-screened for development of diabetic retinopathy (DR). FMD/PWV ratio was calculated as a composite risk biomarker of vascular function that takes into account both endothelial function and arterial stiffness.
Results: At baseline 37 patients had established DR and 43 were free of DR. During follow-up 8 patients developed new DR (NDR). Interestingly, in the subgroup of patients free of DR at baseline, those that developed new DR had higher baseline HbA1c(%) levels compared to the group that did not develop NDR (NoDR) (6.4+/-0.10% vs. 7.3+/-0.19%, p<0.05). Moreover, the composite index of FMD/PWV was significantly lower in the NDR compared to NoDR group (0.50+/-0.4% vs. 0.78+/-0.7%, p<0.05) and comparable to patients with already established DR at baseline.
Conclusions: Poorer glycaemic control and increased FMD to PWV ratio at baseline were strongly associated with the development of new diabetic retinopathy. A composite vascular risk score marker based on the assessment of both endothelial function and arterial stiffness could be used for the risk stratification of microvascular disease progression in T2D patients.
Poster Hall, Hall C
Friday, March 17, 2017, 3:45 p.m.-4:30 p.m.
Session Title: Vascular Medicine: Novel Risk Measures in Arterial Diseases
Abstract Category: 40. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1167-357
- 2017 American College of Cardiology Foundation